Foundayo Tablets

Foundayo has received MHRA approval and you can now place your pre-order today for delivery when stock is available.

Orforglipron is a new medication recently gaining MHRA approval for its use in type 2 diabetes and weight management. As with most other weight loss medications, it is a GLP-1 agonist designed to help people lose weight and lower blood sugar levels.

Available as an oral pill, in clinical trials orforglipron was taken once daily - a contrast to the once weekly injections such as Mounjaro or Wegovy.

Orforglipron at a glance

What Is Orforglipron?

Orforglipron, or the branded Foundayo is a new weight loss medication formulated as a once-daily tablet. Developed by Eli Lilly, it belongs to the GLP-1 class of medications.

Unlike earlier GLP-1 treatments formulated as peptides, which require strict administration methods, orforglipron is a small-molecule non-peptide compound. Because of this, the tablet does not need any strict dietary restrictions, and can be taken with or without food, at any time of day - offering ease of administration.

How Does Orforglipron Work?

As a GLP-1 agonist, orforglipron activates the natural GLP-1 (glucagon-like peptide-1) hormone. It acts on receptors in the brain and digestive system to regulate hunger by:

• Reducing food noise - by increasing feelings of fullness, reducing cravings and thoughts about food.

• Delaying stomach emptying - helping you feel fuller for longer after a meal.

• Regulating blood sugar levels - by stimulating insulin production when sugar levels are high,

Who Can Take Orforglipron?

Orforglipron is licensed for use in adults with:

• A body mass index (BMI) of 30 or above

• A BMI of 27 to 30 with a weight-related health condition such as high blood pressure or high cholesterol.

The treatment must be used alongside a reduced-calorie diet and increased physical activity levels.

Who Should Not Take Orforglipron?

Foundayo is not suitable for everyone. It should not be taken by:

• Anyone with a personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

• Patients who are allergic to orforglipron or any of its ingredients.

How To Take Orforglipron

Orforglipron is taken as a tablet, taken once everyday. Due to the way it is formulated as a small-molecule, it offers greater flexibility over other oral GLP-1 treatments, which require strict fasting rules.

The new orforglipron tablet:

• Can be taken at any time of day.

• Can be taken with or without food.

• Can be taken with any liquid, without restriction on water volume.

• Tablets must be swallowed whole, do not cut, crush, chew or disperse them.

Patients new to treatment must start at the initiation dose of 0.8mg once daily. This is taken for 30 days before increasing further. This process allows the body to adjust to treatment safely, minimising the risk of side effects.

How Effective Is Orforglipron?

Regulatory approval is supported by data from clinical trials.

In the ATTAIN-1 phase 3 trial, over a 72-week period:

• Participants taking the highest orforglipron dose achieved an average weight loss of 12.4% compared to 0.9% in the placebo group.

• 60% of participants lost 10% of their initial body weight, whilst 40% of participants lost 15%

In addition to weight loss marker, the medication led to significant improvements in cardiovascular risk factors, including:

• Average of 11.1cm reduction in waist circumference.

• 21.6% reduction in triglycerides.

• 47.7% reduction in high-sensitivity C-reactive protein (hsCRP) - a marker of inflammation.

Orforglipron vs Other Weight Loss Treatments.

Key Takeaways:

• Founday vs Mounjaro - Foundayo offers a needle-free convenient option whilst Mounjaro has a dual-receptor action in a weekly dose.

• Foundayo vs Wegovy injection - Both are GLP-1 agonists but Foundayo offers effectiveness without the need for refrigeration or injecting.

• Foundayo vs Wegovy tablets - Unlike Wegovy tablets which must be taken on an empty stomach, followed by a 30 minute waiting period for food/drink, Foundayo can be taken without any dietary restrictions.

Side Effects of Orforglipron

As with all medication, Foundayo can cause side effects, though not everyone gets them. In line with other GLP-1 agonists, most side effects involve the digestive system, especially when starting treatment or increasing the dose.

Clinical Evidence and Ongoing Research

In addition to the ATTAIN-1 trial, which demonstrated the effectiveness of orforglipron in weight management, reduction in cardiovascular risk factors and inflammatory factors, the following trials have also been conducted:

• ATTAIN-2 - for those managing weight and type 2 diabetes. This trial demonstrated a 10.5% average weight loss along with a 1.8% point reduction in HbA1c levels.

• ATTAIN-MAINTAIN - confirms Foundayo’s long-term safety profile and its ability to help patients maintain their weight loss over extended periods.

How To Support Your Weight Loss While Taking Orforglipron

Orforglipron is an effective weight management solution, but ideal results which last depend on incorporating sustainable lifestyle changes:

• Prioritise protein. A reduced appetite can lower food intake. Aim for higher protein meals to preserve lean muscle mass.

• Stay hydrated. Consistent hydration reduces the risk of side effects and dehydration-related kidney problems.

• Resistance exercise. Combine treatment with strength training to preserve metabolism.

• Fibre. Increased fibre intake can help prevent constipation.

Why Choose Quick Meds for GLP-1 Weight Loss Treatments?

Quick Meds provides a safe, discreet and regulated UK healthcare service, all from the comfort of your own home:

• GPhC Regulated. Fully licensed UK pharmacy operating under strict clinical standard.

• Expert Clinical Oversight. Every medication request is required by qualified UK based prescribers, specialising in weight management.

• Discreet Delivery. Fast, tracked UK delivery in plain packaging, to protect your privacy.

How can I get Orforglipron at Quick Meds?

Accessing Foundayo from Quickmeds is streamlined in the following process:

• Online Consultation - complete an online consultation which asks about your weight, medical history and if you take other medication.

• Clinical Review - A UK-registered prescriber reviews your profile, ensuring clinical safety.

• Prescription Approval - Once approved, a prescription is generated within our GPhC-registered pharmacy.

• Dispensing & Delivery - Once dispensed, all orders are packaged securely in plain, discreet packaging and delivered through tracked methods straight to your door.