Orforglipron Dosing Explained

How to take Orforglipron

Orforglipron is a tablet that is taken once daily.

Unlike other weight loss treatments, Orforglipron can be taken with or without food.
There are no special dietary requirements or adjustments when taking this medication, making it easier to fit into your daily routine.

For optimum results:

• Take your tablet once a day

• Swallow the tablet whole with water

• Try to take your medication at the same time each day

• Combine your treatment with regular exercise and balanced meals

• Avoid taking breaks in treatment

If you are taking any other medication, prescribed or over the counter, it is important that you let your prescriber know.

Certain medications, known as CYP3A4 inhibitors, impact the way your body breaks down Orforglipron. Your prescriber may need to adjust your dose if you take any of these medicines.
A few examples of CYP3A4 inhibitors include:

• Some antibiotics - clarithromycin and erythromycin

• Certain medicines for your heart - diltiazem, verapamil, amiodarone

• Antifungals - ketoconazole, itraconazole and fluconazole

• Grapefruit and grapefruit juice

If you are unsure, let your prescriber know and they will advise you accordingly.

Simvastatin is a medication that is used to treat high cholesterol levels. Your dose should not exceed 20mg when used alongside Oroflipron. If you take simvastatin, make your prescriber aware.

Foundayo doses and dosing schedule

The dose of Orforglipron will be gradually increased - this is to help your body adjust, become familiar with the medication and reduce the likelihood of side effects such as nausea, vomiting, constipation and diarrhoea.

Foundayo (Orforglipron) will be available in 6 strengths: 0.8mg, 2.5mg, 5.5mg, 9mg, 14.5mg and 17.2mg.

When starting treatment, you will begin with 0.8mg. The rate at which your dose increases will depend on the benefits of treatment and how well you tolerate the medication. You will need to take each dose for a minimum of 30 days before increasing.

For example, you will start treatment at a dose of 0.8mg for 30 days. If you tolerate this well, you can increase to 2.5mg. 17.2mg will be the maximum daily dose.

What if I miss a dose?

If you miss a dose of Orforglipron:

• Take it as soon as you remember - do not take more than one tablet per day

• If it is almost time for your next scheduled dose, skip the missed dose and take your next dose at the usual time

• Do not take an extra dose to make up for a missed one

• If you have missed taking Orforglipron for 7 days or more, contact your prescriber

If you are unsure about what to do after missing a dose, give us a call on 0121 628 5318, email or send us a message or contact us via the form on our website.

Tips for taking Orforglipron

Building a routine around taking your medication can help you remember to take your medication. You may find it useful to:

• Set a daily alarm or reminder

• Keep your medication somewhere you will see it (always keep out of reach of children)

• Take it at the same time as another regular habit - such as brushing your teeth or having your morning coffee

You can take Foundayo (Orforglirpon) with or without food. There are no food or drink restrictions, meaning you can easily fit it into your routine.