Rybelsus 14mg tablets

  • Contains Semaglutide 14mg
  • Once daily dosing
  • Tablet form
  • Used in Type 2 Diabetes
Rybelsus 14mg tablets contain the active ingredient Semaglutide (at a strength of 14mg) and is used in the treatment of Type 2 Diabetes.
This is a prescription product subject to particular requirements. If you have any queries about this product, please get in touch. 



Rybelsus (active ingredient, Semaglutide) is the first and only prescription GLP-1 pill medicine, taken once daily that, along with diet and exercise, may help lower blood sugar and A1C in adults with type 2 diabetes. Rybelsus comes in 3 different dosages: 3 mg, 7 mg and 14 mg.

Rybelsus lowers blood sugar in 3 ways:

  1. Increases insulin released from the pancreas
  2. Decreases sugar released from the liver
  3. Slows food leaving the stomach after eating.

Once-a-day Rybelsus is proven to significantly lower A1C.

In a 6-month long study, the majority of people taking Rybelsus reached an A1C of less than 7%. Nearly 7 out of 10 people taking 7 mg of Rybelsus reached an A1C of less than 7%. Nearly 8 out of 10 people taking 14 mg of Rybelsus reached an A1C of less than 7%. **

**Results are from a 6-month medical study. Participants were 703 adults with type 2 diabetes. The study compared 7 mg Rybelsus and 14 mg Rybelsus with a sugar pill when both were added to diet and exercise. People who took a sugar pill had a 0.3% lowering of A1C, and 31% reached an A1C goal of <7%.

While not made for weight loss, Rybelsus may help you lose some weight. ***please note, Rybelsus is not licensed for weight loss in the UK***

In the same 6-month long study, people lost around 8 pounds. These people weighed an average of 194 pounds and took 14 mg of Rybelsus. People who weighed an average of 196 pounds and took 7 mg of Rybelsus lost around 5 pounds. **

**Results are from a 6-month medical study. Participants were 703 adults with type 2 diabetes. The study compared 7 mg Rybelsus and 14 mg Rybelsus with a sugar pill when both were added to diet and exercise. People who weighed an average of 195 pounds and took a sugar pill lost around 3 pounds. While many people in medical study lost weight, some did gain weight.

Rybelsus does not increase the risk of major cardiovascular events such as heart attack, stroke, or death.

In a cardiovascular safety study, 3183 adults with type 2 diabetes and who were at a high risk of cardiovascular events occurring were treated once daily with either 14 mg Rybelsus or a sugar pill in addition to their usual diabetes and cardiovascular medications.

Rybelsus is not recommended as the first choice of medicine for treating diabetes

It is not known if Rybelsus can be used in people who have had pancreatitis (inflammation of the pancreas)

Rybelsus is not for use in people with type 1 diabetes

It is not known if Rybelsus is safe and effective for use in children under 18 years of age

How to use

Rybelsus tablets should be taken on an empty stomach when you first wake up in the morning, with a sip of plain water (but not more than 4 ounces). Do not split, crush or chew the pill, swallow Rybelsus whole. After 30 mins you can eat, drink or take other oral medicines (that are safe to take alongside Rybelsus).

If you miss a dose of Rybelsus, skip the missed dose and go back to your normal schedule (the next dose should be taken on the next day).

Rybelsus works best if you eat 30-60 minutes after taking it.

Side effects

As with any medication Rybelsus can cause side effects in some people – although not everybody will experience these.

Before you take Rybelsus it is important to familiarise yourself with the patient information leaflet enclosed with your treatment.

If you have any concerns or queries you can contact one of our experienced pharmacists.

The most common side effects of Rybelsus may include nausea, stomach (abdominal) pain, diarrhoea, decreased appetite, vomiting, and constipation. Nausea, vomiting, and diarrhoea are most common when you first start Rybelsus.

Rybelsus may cause serious side effects, including:
  • Inflammation of your pancreas (pancreatitis). Stop using Rybelsus and call your doctor right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back.
  • Changes in vision. Tell your doctor if you have changes in vision during treatment with Rybelsus.
  • Low blood sugar (hypoglycaemia). Your risk for getting low blood sugar may be higher if you use Rybelsus with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin.
  • Signs and symptoms of low blood sugar may include:
    • Dizziness or light-headedness
    • Blurred vision
    • Anxiety, irritability, or mood changes
    • Sweating
    • Slurred speech
    • Hunger
    • Confusion or drowsiness
    • Shakiness
    • Weakness
    • Headache
    • Fast heartbeat
  • Kidney problems (kidney failure). In people who have kidney problems, diarrhoea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems to get worse. It is important for you to drink fluids to help reduce your chance of dehydration.
  • Serious allergic reactions. Stop using Rybelsus and get medical help right away, if you have any symptoms of a serious allergic reaction including:
    • Swelling of your face, lips, tongue or throat
    • Problems breathing or swallowing
    • Severe rash or itching
    • Fainting or feeling dizzy
    • Very rapid heartbeat

Cautions & Warnings

Rybelsus may cause serious side effects, including:

Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, Rybelsus and medicines that work like Rybelsus caused thyroid tumors, including thyroid cancer. It is not known if Rybelsus will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people

Do not use Rybelsus if:

  • you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
  • you have had a serious allergic reaction to semaglutide or any of the ingredients in Rybelsus.
  • Before using Rybelsus, tell your doctor if you have any other medical conditions, including if you:
  • have or have had problems with your pancreas or kidneys
  • have a history of vision problems related to your diabetes
  • are pregnant or plan to become pregnant. It is not known if Rybelsus will harm your unborn baby. You should stop using Rybelsus 2 months before you plan to become pregnant. Talk to your healthcare provider about the best way to control your blood sugar if you plan to become pregnant or while you are pregnant
  • are breastfeeding or plan to breastfeed. Breastfeeding is not recommended during treatment with Rybelsus.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Rybelsus may affect the way some medicines work and some medicines may affect the way Rybelsus works.

Patient information leaflet

You can find the patient information leaflet here